Analgesic effects of oxycodone hydrochloride injection after laparoscopic cholecystectomy and influence on substance P, 5-hydroxytryptamine, and patient-controlled intravenous analgesia

Abstract Introduction We sought out to evaluate the effects of oxycodone hydrochloride injection on laparoscopic cholecystectomy (LC), substance P, 5-hydroxytryptamine (5-HT), and patient-controlled intravenous analgesia (PCIA). Materials Methods A total 120 eligible patients were randomly divided into an observation group (n=60) control (n=60). Oxycodone (0.07 mg/kg) fentanyl (0.7 μg/kg) intravenously injected during LC. Substance P 5-HT detected by ELISA. Results Heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO 2 ) recorded. Visual analogue scale (VAS), Ramsay scores, incidence rates adverse reactions The was less prone agitation, with affected HR, MAP SpO recovery. Before after extubation, upon leaving recovery room, increased more slowly in group. After had higher VAS scores a reactions. Using before end LC does not delay awakening or affect but reduces hemodynamic fluctuations, agitation release 5-HT. It has high safety stable circulation Conclusions used PCIA effectively mitigates postoperative pain, milder reactions, which is superior fentanyl.